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KMID : 0939920150470010115
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대한암학회지
2015 Volume.47 No. 1 p.115 ~ p.119
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Long-Term Survival after T-cell Lymphoblastic Lymphoma Treated with One Cycle of Hyper-CVAD Regimen
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Ryu Il-Hwan
Cho In-Sung
Ryu Ah-Jeong
Kim Min-Gyu
Jeon Jae-Woong
Kim Joo-Seok
Lee Jae-Joon
Choi Ji-Wook
Kang Dong-Wook
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Abstract
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T-lymphoblastic lymphoma (T-LBL) is a rare form of aggressive non-Hodgkin’s lymphoma. The standard approach for management of T-LBL involves intensive multiagent chemotherapy regimens for induction and consolidation phases with central nervous system prophylaxis and a maintenance phase lasting 12-18 months. We report on a case of long-term survival after one cycle of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) and high-dose methotrexate. A 30-year-old woman diagnosed with T-LBL with a large mediastinal mass underwent one cycle of hyper-CVAD. Four days after the start of treatment, the mediastinal mass was markedly reduced. Treatment continued with one cycle of consolidation chemotherapy, comprising high-dose methotrexate and high-dose cytarabine. The patient then refused all further chemotherapeutic treatment. Seven years have passed without relapse.
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KEYWORD
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Precursor T-cell lymphoblastic leukemia-lymphoma, Remission induction, CVAD protocol
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